A study identified Heat Shock Transcription Factor 1 (HSF1) as a key protein driving the renewal of leukemia stem cells in Acute Myeloid Leukemia (AML). The work is featured in Nature Communications Cancer Highlights.
Posts tagged: AML
Sisu Pharma exploits cellular stress by directly targeting the transcription factor Heat Shock Factor 1 (HSF1), the Central Regulator of the heat shock response. Our HSF1 targeting platform (HI-LiTe) is being leveraged to deliver selective HSF1 degraders for oncology and therapies for use in neurodegenerative conditions and infection, providing a unique approach to treating these devastating diseases.
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