SISU PHARMA, INC.

TARGETING THE STRESS PROTECTION RESPONSE

Sisu Pharma is exploiting the power of the cellular stress response, directly targeting Heat Shock Factor 1 (HSF1) - the key regulator of the heat shock response. Through our innovative HSF1 targeting platform, HI-LiTe, we are advancing selective HSF1 degraders for oncology and activators for neurodegenerative diseases. Our first-in-class compounds have already demonstrated exceptional efficacy in therapy-resistant cancer models, where existing treatments fail. At Sisu, we are not just pushing the boundaries of treatment; we are redefining what's possible in the fight against some of the most challenging diseases.

Picture1

FOUNDERS AND SCIENTIFIC ADVISORY BOARD

Sisu Pharma is led by a team of world-class scientists with decades of experience and success in basic and translational oncology research and FDA-approved cancer drug development

staff4

Sean E. O’Brien, Ph.D.

Founder, Chief Executive Officer
Dr. O’Brien has over 20 years of diverse experience in the drug discovery and development field and has expertise in business development, corporate strategy, and oncology therapeutic programs. He has ...
staff1

Dennis J. Thiele, Ph.D.

Founder, Chief Scientific Officer, Member Scientific Advisory Board
Dr. Thiele is an internationally recognized authority on the cellular stress-protective Heat Shock Factor 1 (HSF1). Dr. Thiele served as the George Barth Geller Distinguished ...
staff2

Jiaoti Huang, M.D. Ph.D.

Founder, Chair Scientific Advisory Board
Dr. Huang serves as Distinguished University Professor of Pathology, Pharmacology and Cancer Biology and Chair of Pathology at the Duke University School of Medicine. Dr. Huang is an internationally renowned ...
Mike_orig_BW

Michael E. Jung, Ph.D.

Member, Scientific Advisory Board
Dr. Jung is the Walter and Shirley Wang Chair of Medicinal Drug Discovery in the Department of Chemistry and Biochemistry at the University of California, Los Angeles (UCLA) and a ...

COLLABORATION AND AFFILIATIONS

Picture1
Picture2
Capture