Dennis J. Thiele
Chief Scientific Officer, Member, Scientific Advisory Board:
Dr. Thiele is an internationally recognized authority on the cellular stress-protective Heat Shock Factor 1 (HSF1). Dr. Thiele served as the George Barth Geller Distinguished Professor of Pharmacology and Cancer Biology at the Duke University School of Medicine over a 35-year career in academia. Dr. Thiele’s accomplishments include solving three-dimensional structures of Heat Shock Factor, discovery of small molecule HSF1 degraders and the identification of roles and regulatory mechanisms for HSF1 in cellular and animal models of disease. Dr. Thiele received his Ph.D. from Rutgers University and carried out Postdoctoral training in the Laboratory of Biochemistry at the National Cancer Institute.